发给老马备查:2 {. v; C+ ~. c% ~& c9 O
滴水察海(69304838) 15:23:23( ~- D( ? Z. u2 j% K! r9 G
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
2 z# o6 y% J" U0 q吉非替尼和S-1连用的依据
3 x- ?. q" ]1 p7 IGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.$ f: A1 S. Z' Q; J* _2 g+ c# m
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* t, z9 @$ ^9 C7 G: l& B7 G这样是不是推理出,耐药后,可以用S-1和培美了?4 s( r* f5 r' x% V7 A U
结论:
+ n2 P, }0 |, Q; C* p4 ]- A) \4 e如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |